The use of hypertonic solutions in sepsis

Frank M.P. Van Haren*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    4 Citations (Scopus)


    Fluid therapy is a key component in the treatment of patients with septic shock. Recent data suggests that hypertonic fluid administration in sepsis may have beneficial effects on the global circulation and the cardiac function that exceed simple intravascular volume expansion. In addition, hypertonic resuscitation may exert specific effects on inflammatory pathways and endothelial function.This review summarizes the current knowledge on this topic and highlights the need for further research to translate some of the promising observations into relevant patient centred outcomes.

    Original languageEnglish
    Pages (from-to)37-41
    Number of pages5
    JournalTrends in Anaesthesia and Critical Care
    Issue number1
    Publication statusPublished - Feb 2013


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