Thiol-ene reaction: A versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR

Qing Feng Li, Yin Yang, Ansis Maleckis, Gottfried Otting, Xun Cheng Su*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    51 Citations (Scopus)

    Abstract

    Site-specific tagging of proteins with paramagnetic lanthanides generates valuable long-range structure restraints for structural biology by NMR spectroscopy. We show that the thiol-ene addition reaction offers a powerful tool for tagging proteins in a chemically stable manner with very small lanthanide tags.

    Original languageEnglish
    Pages (from-to)2704-2706
    Number of pages3
    JournalChemical Communications
    Volume48
    Issue number21
    DOIs
    Publication statusPublished - 13 Feb 2012

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