Three-dimensional analysis of cortical bone structure using X-ray micro-computed tomography

A. C. Jones; A. P. Sheppard; R. M. Sok; C. H. Arns; A. Limaye; H. Averdunk; A. Brandwood; A. Sakellariou; T. J. Senden; B. K. Milthorpe; M. A. Knackstedt

doi:10.1016/j.physa.2004.03.046

Three-dimensional analysis of cortical bone structure using X-ray micro-computed tomography

A. C. Jones, A. P. Sheppard, R. M. Sok, C. H. Arns, A. Limaye, H. Averdunk, A. Brandwood, A. Sakellariou, T. J. Senden, B. K. Milthorpe, M. A. Knackstedt^*

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

36 Citations (Scopus)

Abstract

We demonstrate the capability of X-ray micro-computed tomography to image the micro-structure of human cortical bone. At 5 μm voxel size we observe the complex morphology of the Haversian network in three dimensions. The local thickness of Haversian canals is measured using a maximal sphere algorithm and found to have a bimodal signature and a mean radius of 19.2 μm. The intra-cortical porosity due to Haversian canals is measured as 3.0%. Both results are in agreement with traditional histomorphometric measurements. We show that at higher resolutions one can resolve the spatial distribution of lacunae in cortical bone.

Original language	English
Pages (from-to)	125-130
Number of pages	6
Journal	Physica A: Statistical Mechanics and its Applications
Volume	339
Issue number	1-2
DOIs	https://doi.org/10.1016/j.physa.2004.03.046
Publication status	Published - 1 Aug 2004
Event	Proceedings of the International Conference New Materials - Canberra, Vic., Australia Duration: 3 Nov 2003 → 7 Nov 2003

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Jones, A. C., Sheppard, A. P., Sok, R. M., Arns, C. H., Limaye, A., Averdunk, H., Brandwood, A., Sakellariou, A., Senden, T. J., Milthorpe, B. K., & Knackstedt, M. A. (2004). Three-dimensional analysis of cortical bone structure using X-ray micro-computed tomography. Physica A: Statistical Mechanics and its Applications, 339(1-2), 125-130. https://doi.org/10.1016/j.physa.2004.03.046

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title = "Three-dimensional analysis of cortical bone structure using X-ray micro-computed tomography",

abstract = "We demonstrate the capability of X-ray micro-computed tomography to image the micro-structure of human cortical bone. At 5 μm voxel size we observe the complex morphology of the Haversian network in three dimensions. The local thickness of Haversian canals is measured using a maximal sphere algorithm and found to have a bimodal signature and a mean radius of 19.2 μm. The intra-cortical porosity due to Haversian canals is measured as 3.0%. Both results are in agreement with traditional histomorphometric measurements. We show that at higher resolutions one can resolve the spatial distribution of lacunae in cortical bone.",

keywords = "Bone morphology, Bone remodelling, Haversian canal, Microtomography",

author = "Jones, {A. C.} and Sheppard, {A. P.} and Sok, {R. M.} and Arns, {C. H.} and A. Limaye and H. Averdunk and A. Brandwood and A. Sakellariou and Senden, {T. J.} and Milthorpe, {B. K.} and Knackstedt, {M. A.}",

year = "2004",

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doi = "10.1016/j.physa.2004.03.046",

language = "English",

volume = "339",

pages = "125--130",

journal = "Physica A: Statistical Mechanics and its Applications",

issn = "0378-4371",

publisher = "Elsevier B.V.",

number = "1-2",

note = "Proceedings of the International Conference New Materials ; Conference date: 03-11-2003 Through 07-11-2003",

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Jones, AC, Sheppard, AP, Sok, RM, Arns, CH, Limaye, A, Averdunk, H, Brandwood, A, Sakellariou, A, Senden, TJ, Milthorpe, BK & Knackstedt, MA 2004, 'Three-dimensional analysis of cortical bone structure using X-ray micro-computed tomography', Physica A: Statistical Mechanics and its Applications, vol. 339, no. 1-2, pp. 125-130. https://doi.org/10.1016/j.physa.2004.03.046

TY - JOUR

T1 - Three-dimensional analysis of cortical bone structure using X-ray micro-computed tomography

AU - Jones, A. C.

AU - Sheppard, A. P.

AU - Sok, R. M.

AU - Arns, C. H.

AU - Limaye, A.

AU - Averdunk, H.

AU - Brandwood, A.

AU - Sakellariou, A.

AU - Senden, T. J.

AU - Milthorpe, B. K.

AU - Knackstedt, M. A.

PY - 2004/8/1

Y1 - 2004/8/1

N2 - We demonstrate the capability of X-ray micro-computed tomography to image the micro-structure of human cortical bone. At 5 μm voxel size we observe the complex morphology of the Haversian network in three dimensions. The local thickness of Haversian canals is measured using a maximal sphere algorithm and found to have a bimodal signature and a mean radius of 19.2 μm. The intra-cortical porosity due to Haversian canals is measured as 3.0%. Both results are in agreement with traditional histomorphometric measurements. We show that at higher resolutions one can resolve the spatial distribution of lacunae in cortical bone.

AB - We demonstrate the capability of X-ray micro-computed tomography to image the micro-structure of human cortical bone. At 5 μm voxel size we observe the complex morphology of the Haversian network in three dimensions. The local thickness of Haversian canals is measured using a maximal sphere algorithm and found to have a bimodal signature and a mean radius of 19.2 μm. The intra-cortical porosity due to Haversian canals is measured as 3.0%. Both results are in agreement with traditional histomorphometric measurements. We show that at higher resolutions one can resolve the spatial distribution of lacunae in cortical bone.

KW - Bone morphology

KW - Bone remodelling

KW - Haversian canal

KW - Microtomography

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U2 - 10.1016/j.physa.2004.03.046

DO - 10.1016/j.physa.2004.03.046

M3 - Conference article

SN - 0378-4371

VL - 339

SP - 125

EP - 130

JO - Physica A: Statistical Mechanics and its Applications

JF - Physica A: Statistical Mechanics and its Applications

IS - 1-2

T2 - Proceedings of the International Conference New Materials

Y2 - 3 November 2003 through 7 November 2003

ER -

Three-dimensional analysis of cortical bone structure using X-ray micro-computed tomography

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