Time to get anxious about the broken hearted?

The close relationship between the emotional world and the heart has been recognized for centuries [1]. As such, the heart has assumed the mantle as the principal metaphor for emotional expression and has often been used to symbolize the human spirit [2]. A significant body of evidence is now accumulating that psychosocial factors are strongly linked to the pathogenesis, expression and prognostic impact of coronary artery disease (CAD) [3]. Of particular note is the predominance of correlations with five particular psychosocial domains: 1) depression; 2) anxiety; 3) personality characteristics; 4) social isolation and low social support, and 5) chronic life stress [3].