TY - JOUR
T1 - Tissue adhesives based on chitosan for biomedical applications
AU - Youn, Jihyun
AU - Patel, Kapil D.
AU - Perriman, Adam W.
AU - Sung, Jung Suk
AU - Patel, Madhumita
AU - Bouchard, Louis S.
AU - Patel, Rajkumar
N1 - Publisher Copyright:
© 2024 The Royal Society of Chemistry.
PY - 2024
Y1 - 2024
N2 - Chitosan bio-adhesives bond strongly with various biological tissues, such as skin, mucosa, and internal organs. Their adhesive ability arises from amino acid and hydroxyl groups in chitosan, facilitating interactions with tissue surfaces through chemical (ionic, covalent, and hydrogen) and physical (chain entanglement) bonding. As non-toxic, biodegradable, and biocompatible materials, chitosan bio-adhesives are a safe option for medical therapies. They are particularly suitable for drug delivery, wound healing, and tissue regeneration. In this review, we address chitosan-based bio-adhesives and the mechanisms associated with them. We also discuss different chitosan composite-based bio-adhesives and their biomedical applications in wound healing, drug delivery, hemostasis, and tissue regeneration. Finally, challenges and future perspectives for the clinical use of chitosan-based bio-adhesives are discussed.
AB - Chitosan bio-adhesives bond strongly with various biological tissues, such as skin, mucosa, and internal organs. Their adhesive ability arises from amino acid and hydroxyl groups in chitosan, facilitating interactions with tissue surfaces through chemical (ionic, covalent, and hydrogen) and physical (chain entanglement) bonding. As non-toxic, biodegradable, and biocompatible materials, chitosan bio-adhesives are a safe option for medical therapies. They are particularly suitable for drug delivery, wound healing, and tissue regeneration. In this review, we address chitosan-based bio-adhesives and the mechanisms associated with them. We also discuss different chitosan composite-based bio-adhesives and their biomedical applications in wound healing, drug delivery, hemostasis, and tissue regeneration. Finally, challenges and future perspectives for the clinical use of chitosan-based bio-adhesives are discussed.
UR - http://www.scopus.com/inward/record.url?scp=85205601960&partnerID=8YFLogxK
U2 - 10.1039/d4tb01362j
DO - 10.1039/d4tb01362j
M3 - Review article
AN - SCOPUS:85205601960
SN - 2050-750X
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
ER -