Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

P. A. Lang; A. Meryk; A. A. Pandyra; D. Brenner; A. Brüstle; H. C. Xu; K. Merches; F. Lang; V. Khairnar; P. Sharma; P. Funkner; M. Recher; N. Shaabani; G. S. Duncan; V. Duhan; B. Homey; P. S. Ohashi; D. Häussinger; P. A. Knolle; N. Honke; T. W. Mak; K. S. Lang

doi:10.1038/cdd.2014.138

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

P. A. Lang, A. Meryk, A. A. Pandyra, D. Brenner, A. Brüstle, H. C. Xu, K. Merches, F. Lang, V. Khairnar, P. Sharma, P. Funkner, M. Recher, N. Shaabani, G. S. Duncan, V. Duhan, B. Homey, P. S. Ohashi, D. Häussinger, P. A. Knolle, N. HonkeT. W. Mak^*, K. S. Lang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

During virus infection and autoimmune disease, inflammatory dendritic cells (iDCs) differentiate from blood monocytes and infiltrate infected tissue. Following acute infection with hepatotropic viruses, iDCs are essential for re-stimulating virus-specific CD8 + T cells and therefore contribute to virus control. Here we used the lymphocytic choriomeningitis virus (LCMV) model system to identify novel signals, which influence the recruitment and activation of iDCs in the liver. We observed that intrinsic expression of Toso (Faim3, FcμR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro. Lack of iDCs in Toso-deficient (Toso -/-) mice reduced CD8 + T-cell function in the liver and resulted in virus persistence. Furthermore, Toso -/- DCs failed to induce autoimmune diabetes in the rat insulin promoter-glycoprotein (RIP-GP) autoimmune diabetes model. In conclusion, we found that Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.

Original language	English
Pages (from-to)	164-173
Number of pages	10
Journal	Cell Death and Differentiation
Volume	22
Issue number	1
DOIs	https://doi.org/10.1038/cdd.2014.138
Publication status	Published - 1 Jan 2015
Externally published	Yes

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10.1038/cdd.2014.138

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Lang, P. A., Meryk, A., Pandyra, A. A., Brenner, D., Brüstle, A., Xu, H. C., Merches, K., Lang, F., Khairnar, V., Sharma, P., Funkner, P., Recher, M., Shaabani, N., Duncan, G. S., Duhan, V., Homey, B., Ohashi, P. S., Häussinger, D., Knolle, P. A., ... Lang, K. S. (2015). Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Cell Death and Differentiation, 22(1), 164-173. https://doi.org/10.1038/cdd.2014.138

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title = "Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection",

abstract = "During virus infection and autoimmune disease, inflammatory dendritic cells (iDCs) differentiate from blood monocytes and infiltrate infected tissue. Following acute infection with hepatotropic viruses, iDCs are essential for re-stimulating virus-specific CD8 + T cells and therefore contribute to virus control. Here we used the lymphocytic choriomeningitis virus (LCMV) model system to identify novel signals, which influence the recruitment and activation of iDCs in the liver. We observed that intrinsic expression of Toso (Faim3, FcμR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro. Lack of iDCs in Toso-deficient (Toso -/-) mice reduced CD8 + T-cell function in the liver and resulted in virus persistence. Furthermore, Toso -/- DCs failed to induce autoimmune diabetes in the rat insulin promoter-glycoprotein (RIP-GP) autoimmune diabetes model. In conclusion, we found that Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.",

author = "Lang, {P. A.} and A. Meryk and Pandyra, {A. A.} and D. Brenner and A. Br{\"u}stle and Xu, {H. C.} and K. Merches and F. Lang and V. Khairnar and P. Sharma and P. Funkner and M. Recher and N. Shaabani and Duncan, {G. S.} and V. Duhan and B. Homey and Ohashi, {P. S.} and D. H{\"a}ussinger and Knolle, {P. A.} and N. Honke and Mak, {T. W.} and Lang, {K. S.}",

year = "2015",

month = jan,

day = "1",

doi = "10.1038/cdd.2014.138",

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Lang, PA, Meryk, A, Pandyra, AA, Brenner, D, Brüstle, A, Xu, HC, Merches, K, Lang, F, Khairnar, V, Sharma, P, Funkner, P, Recher, M, Shaabani, N, Duncan, GS, Duhan, V, Homey, B, Ohashi, PS, Häussinger, D, Knolle, PA, Honke, N, Mak, TW & Lang, KS 2015, 'Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection', Cell Death and Differentiation, vol. 22, no. 1, pp. 164-173. https://doi.org/10.1038/cdd.2014.138

TY - JOUR

T1 - Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

AU - Lang, P. A.

AU - Meryk, A.

AU - Pandyra, A. A.

AU - Brenner, D.

AU - Brüstle, A.

AU - Xu, H. C.

AU - Merches, K.

AU - Lang, F.

AU - Khairnar, V.

AU - Sharma, P.

AU - Funkner, P.

AU - Recher, M.

AU - Shaabani, N.

AU - Duncan, G. S.

AU - Duhan, V.

AU - Homey, B.

AU - Ohashi, P. S.

AU - Häussinger, D.

AU - Knolle, P. A.

AU - Honke, N.

AU - Mak, T. W.

AU - Lang, K. S.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - During virus infection and autoimmune disease, inflammatory dendritic cells (iDCs) differentiate from blood monocytes and infiltrate infected tissue. Following acute infection with hepatotropic viruses, iDCs are essential for re-stimulating virus-specific CD8 + T cells and therefore contribute to virus control. Here we used the lymphocytic choriomeningitis virus (LCMV) model system to identify novel signals, which influence the recruitment and activation of iDCs in the liver. We observed that intrinsic expression of Toso (Faim3, FcμR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro. Lack of iDCs in Toso-deficient (Toso -/-) mice reduced CD8 + T-cell function in the liver and resulted in virus persistence. Furthermore, Toso -/- DCs failed to induce autoimmune diabetes in the rat insulin promoter-glycoprotein (RIP-GP) autoimmune diabetes model. In conclusion, we found that Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.

AB - During virus infection and autoimmune disease, inflammatory dendritic cells (iDCs) differentiate from blood monocytes and infiltrate infected tissue. Following acute infection with hepatotropic viruses, iDCs are essential for re-stimulating virus-specific CD8 + T cells and therefore contribute to virus control. Here we used the lymphocytic choriomeningitis virus (LCMV) model system to identify novel signals, which influence the recruitment and activation of iDCs in the liver. We observed that intrinsic expression of Toso (Faim3, FcμR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro. Lack of iDCs in Toso-deficient (Toso -/-) mice reduced CD8 + T-cell function in the liver and resulted in virus persistence. Furthermore, Toso -/- DCs failed to induce autoimmune diabetes in the rat insulin promoter-glycoprotein (RIP-GP) autoimmune diabetes model. In conclusion, we found that Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.

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U2 - 10.1038/cdd.2014.138

DO - 10.1038/cdd.2014.138

M3 - Article

SN - 1350-9047

VL - 22

SP - 164

EP - 173

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 1

ER -

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

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