Abstract
Compounds 1-6 and 11 representing key members of the marinoquinoline family of natural products, together with the related marine alkaloid aplidiopsamine A (12), have been synthesized using various combinations of palladium-catalyzed Ullmann cross-coupling and reductive cyclization processes involving a C3-arylated pyrrole as the common intermediate. These natural products have been characterized by single-crystal X-ray analyses and evaluated as inhibitors of acetylcholinesterase (AChE) with congener 2 proving to be the most active.
Original language | English |
---|---|
Pages (from-to) | 650-663 |
Number of pages | 14 |
Journal | Journal of Organic Chemistry |
Volume | 85 |
Issue number | 2 |
DOIs | |
Publication status | Published - 17 Jan 2020 |