Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Xingjun Xu, Hye Sun Kim, Wei Min Chen, Xiang Ma, Galen J. Correy, Martin G. Banwell*, Colin J. Jackson, Anthony C. Willis, Paul D. Carr

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.

    Original languageEnglish
    Pages (from-to)4044-4053
    Number of pages10
    JournalEuropean Journal of Organic Chemistry
    Volume2017
    Issue number27
    DOIs
    Publication statusPublished - 25 Jul 2017

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