Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Xingjun Xu; Hye Sun Kim; Wei Min Chen; Xiang Ma; Galen J. Correy; Martin G. Banwell; Colin J. Jackson; Anthony C. Willis; Paul D. Carr

doi:10.1002/ejoc.201700705

Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Xingjun Xu, Hye Sun Kim, Wei Min Chen, Xiang Ma, Galen J. Correy, Martin G. Banwell^*, Colin J. Jackson, Anthony C. Willis, Paul D. Carr

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.

Original language	English
Pages (from-to)	4044-4053
Number of pages	10
Journal	European Journal of Organic Chemistry
Volume	2017
Issue number	27
DOIs	https://doi.org/10.1002/ejoc.201700705
Publication status	Published - 25 Jul 2017

Access to Document

10.1002/ejoc.201700705

Cite this

@article{144cdf0545ed4694b778ced09754047c,

title = "Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase",

abstract = "The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.",

keywords = "AChE inhibition, Alkaloids, Biaryls, Cross-coupling, Lycosinine A, Zephycandidine III",

author = "Xingjun Xu and Kim, \{Hye Sun\} and Chen, \{Wei Min\} and Xiang Ma and Correy, \{Galen J.\} and Banwell, \{Martin G.\} and Jackson, \{Colin J.\} and Willis, \{Anthony C.\} and Carr, \{Paul D.\}",

note = "Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2017",

month = jul,

day = "25",

doi = "10.1002/ejoc.201700705",

language = "English",

volume = "2017",

pages = "4044--4053",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-VCH Verlag GmbH",

number = "27",

}

TY - JOUR

T1 - Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

AU - Xu, Xingjun

AU - Kim, Hye Sun

AU - Chen, Wei Min

AU - Ma, Xiang

AU - Correy, Galen J.

AU - Banwell, Martin G.

AU - Jackson, Colin J.

AU - Willis, Anthony C.

AU - Carr, Paul D.

PY - 2017/7/25

Y1 - 2017/7/25

N2 - The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.

AB - The title alkaloids, 1 and 2, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2.

KW - AChE inhibition

KW - Alkaloids

KW - Biaryls

KW - Cross-coupling

KW - Lycosinine A

KW - Zephycandidine III

UR - https://www.scopus.com/pages/publications/85025650780

U2 - 10.1002/ejoc.201700705

DO - 10.1002/ejoc.201700705

M3 - Article

SN - 1434-193X

VL - 2017

SP - 4044

EP - 4053

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 27

ER -

Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Abstract

Access to Document

Other files and links

Fingerprint

Cite this