TY - JOUR
T1 - Total syntheses of the resorcylic acid lactone neocosmosin a and its enantiomer
AU - Zhang, Yiwen
AU - Dlugosch, Michael
AU - Jübermann, Martin
AU - Banwell, Martin G.
AU - Ward, Jas S.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - A total synthesis of the structure, 1, assigned to the recently reported resorcylic acid lactone (RAL) neocosmosin A has been established. Olefin-cross metathesis, ring-closing metathesis, palladium-catalyzed Meinwald rearrangement, and Mitsunobu esterification reactions were used as key steps. A late-stage and simple modification to the reaction sequence also provided compound ent-1 that, in fact, represents the true structure of the natural product.
AB - A total synthesis of the structure, 1, assigned to the recently reported resorcylic acid lactone (RAL) neocosmosin A has been established. Olefin-cross metathesis, ring-closing metathesis, palladium-catalyzed Meinwald rearrangement, and Mitsunobu esterification reactions were used as key steps. A late-stage and simple modification to the reaction sequence also provided compound ent-1 that, in fact, represents the true structure of the natural product.
UR - http://www.scopus.com/inward/record.url?scp=84928910864&partnerID=8YFLogxK
U2 - 10.1021/acs.joc.5b00590
DO - 10.1021/acs.joc.5b00590
M3 - Article
SN - 0022-3263
VL - 80
SP - 4828
EP - 4833
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 9
ER -