Total synthesis and structural revision of the alkaloid IncargranineB

Patrick D. Brown, Anthony C. Willis*, Michael S. Sherburn, Andrew L. Lawrence

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    45 Citations (Scopus)

    Abstract

    Seeing double: Consideration of the biosynthetic origins of incargranineB, which was originally assigned an unprecedented indolo[1.7]naphthyridine structure, led to the proposal of a dipyrroloquinoline framework as a more biosynthetically feasible structure (see scheme; Piv=pivaloyl). This hypothesis was validated by a short biomimetic synthesis of incargranineB.

    Original languageEnglish
    Pages (from-to)13273-13275
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Volume52
    Issue number50
    DOIs
    Publication statusPublished - 9 Dec 2013

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