Total synthesis of sordaricin

Lewis N. Mander; Regan J. Thomson

doi:10.1021/ol0342599

Total synthesis of sordaricin

Lewis N. Mander^*, Regan J. Thomson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

(Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.

Original language	English
Pages (from-to)	1321-1324
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	8
DOIs	https://doi.org/10.1021/ol0342599
Publication status	Published - 17 Apr 2003

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10.1021/ol0342599

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title = "Total synthesis of sordaricin",

abstract = "(Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.",

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AB - (Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.

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Total synthesis of sordaricin

Abstract

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