Total synthesis of sordaricin

Lewis N. Mander; Regan J. Thomson

doi:10.1021/ol0342599

Total synthesis of sordaricin

Lewis N. Mander^*, Regan J. Thomson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

(Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.

Original language	English
Pages (from-to)	1321-1324
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	8
DOIs	https://doi.org/10.1021/ol0342599
Publication status	Published - 17 Apr 2003

Access to Document

10.1021/ol0342599

Cite this

@article{87a34b6996d741c5af9c4e8041b531f4,

title = "Total synthesis of sordaricin",

abstract = "(Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.",

author = "Mander, \{Lewis N.\} and Thomson, \{Regan J.\}",

year = "2003",

month = apr,

day = "17",

doi = "10.1021/ol0342599",

language = "English",

volume = "5",

pages = "1321--1324",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Total synthesis of sordaricin

AU - Mander, Lewis N.

AU - Thomson, Regan J.

PY - 2003/4/17

Y1 - 2003/4/17

N2 - (Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.

AB - (Matrix presented) The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.

UR - https://www.scopus.com/pages/publications/0037925370

U2 - 10.1021/ol0342599

DO - 10.1021/ol0342599

M3 - Article

SN - 1523-7060

VL - 5

SP - 1321

EP - 1324

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Total synthesis of sordaricin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this