Total synthesis of (±)-Vibsanin e

Brett D. Schwartz; Justin R. Denton; Huw M.L. Davies; Craig M. Williams

doi:10.1071/CH09267

Total synthesis of (±)-Vibsanin e

Brett D. Schwartz, Justin R. Denton, Huw M.L. Davies, Craig M. Williams

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Vibsanin E (1), a structurally rare complex diterpene, consisting of a compact 3-oxatricyclo[6.3.2.0^5,10] tridecane core and an unprecedented 3,3-dimethylacroyl enol ester functional group, formulate a considerable synthetic challenge. Williams and Davies failed to independently synthesize this nemesis, however, a 'two heads are better than one' approach delivered the first total synthesis of the molecule, since its diamond aniversary isolation.

Original language	English
Pages (from-to)	980-982
Number of pages	3
Journal	Australian Journal of Chemistry
Volume	62
Issue number	9
DOIs	https://doi.org/10.1071/CH09267
Publication status	Published - 2009
Externally published	Yes

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10.1071/CH09267

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Total synthesis of (±)-Vibsanin e

Abstract

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