Towards the total synthesis of 3-hydroxyvibsanin e

Brett D. Schwartz; Justin R. Denton; Paul V. Bernhardt; Huw M.L. Davies; Craig M. Williams

doi:10.1055/s-0029-1216912

Towards the total synthesis of 3-hydroxyvibsanin e

Brett D. Schwartz, Justin R. Denton, Paul V. Bernhardt, Huw M.L. Davies, Craig M. Williams

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The synthesis of a silyl-protected derivative of 3-hydroxyvibsanin E has been achieved. The key step is a regio-and stereoselective C-H hydroxylation of an advanced tricyclic intermediate by means of a Rubottom oxidation.

Original language	English
Pages (from-to)	2840-2846
Number of pages	7
Journal	Synthesis
Issue number	17
DOIs	https://doi.org/10.1055/s-0029-1216912
Publication status	Published - 2009
Externally published	Yes

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title = "Towards the total synthesis of 3-hydroxyvibsanin e",

abstract = "The synthesis of a silyl-protected derivative of 3-hydroxyvibsanin E has been achieved. The key step is a regio-and stereoselective C-H hydroxylation of an advanced tricyclic intermediate by means of a Rubottom oxidation.",

keywords = "C-H hydroxylation, Hydroxyvibsanin E, Rubottom oxidation",

author = "Schwartz, {Brett D.} and Denton, {Justin R.} and Bernhardt, {Paul V.} and Davies, {Huw M.L.} and Williams, {Craig M.}",

year = "2009",

doi = "10.1055/s-0029-1216912",

language = "English",

pages = "2840--2846",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "17",

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T1 - Towards the total synthesis of 3-hydroxyvibsanin e

AU - Schwartz, Brett D.

AU - Denton, Justin R.

AU - Bernhardt, Paul V.

AU - Davies, Huw M.L.

AU - Williams, Craig M.

PY - 2009

Y1 - 2009

N2 - The synthesis of a silyl-protected derivative of 3-hydroxyvibsanin E has been achieved. The key step is a regio-and stereoselective C-H hydroxylation of an advanced tricyclic intermediate by means of a Rubottom oxidation.

AB - The synthesis of a silyl-protected derivative of 3-hydroxyvibsanin E has been achieved. The key step is a regio-and stereoselective C-H hydroxylation of an advanced tricyclic intermediate by means of a Rubottom oxidation.

KW - C-H hydroxylation

KW - Hydroxyvibsanin E

KW - Rubottom oxidation

UR - http://www.scopus.com/inward/record.url?scp=70449371882&partnerID=8YFLogxK

U2 - 10.1055/s-0029-1216912

DO - 10.1055/s-0029-1216912

M3 - Article

SN - 0039-7881

SP - 2840

EP - 2846

JO - Synthesis

JF - Synthesis

IS - 17

ER -

Towards the total synthesis of 3-hydroxyvibsanin e

Abstract

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