Transfection of plasmodium falciparum

Melanie Rug, Alexander Maier

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    27 Citations (Scopus)

    Abstract

    Genetic manipulation of Plasmodium falciparum remains very challenging, mainly due to the parasite genome's high A/T-richness and low transfection efficiency. This chapter includes methods for generating transient and stable transfections by electroporation, allelic replacement with tagged genes, gene deletion, and the analysis of all the above.

    Original languageEnglish
    Title of host publicationMalaria: Methods and Protocols
    Subtitle of host publicationMethods and Protocols
    EditorsRobert Menard
    Place of PublicationUSA
    PublisherHumana Press
    Pages75-98
    Number of pages24
    Volume923
    Edition2nd
    ISBN (Print)9781627030250
    DOIs
    Publication statusPublished - 2013

    Publication series

    NameMethods in Molecular Biology
    Volume923
    ISSN (Print)1064-3745

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