Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys

Carrie Ho; Steven Wu; Joshua D. Amos; Lisa Colvin; Shannon D. Smith; Andrew B. Wilks; Todd DeMarco; Christie Brinkley; Thomas N. Denny; Joern E. Schmitz; Allen G. Rodrigo; Sallie R. Permar

doi:10.1128/JVI.01643-13

Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys

Carrie Ho, Steven Wu, Joshua D. Amos, Lisa Colvin, Shannon D. Smith, Andrew B. Wilks, Todd DeMarco, Christie Brinkley, Thomas N. Denny, Joern E. Schmitz, Allen G. Rodrigo, Sallie R. Permar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

Original language	English
Pages (from-to)	11292-11299
Number of pages	8
Journal	Journal of Virology
Volume	87
Issue number	20
DOIs	https://doi.org/10.1128/JVI.01643-13
Publication status	Published - 2013
Externally published	Yes

Access to Document

10.1128/JVI.01643-13

Cite this

@article{5af048da77244bb1919cf96d9e7f13c5,

title = "Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys",

abstract = "Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.",

author = "Carrie Ho and Steven Wu and Amos, {Joshua D.} and Lisa Colvin and Smith, {Shannon D.} and Wilks, {Andrew B.} and Todd DeMarco and Christie Brinkley and Denny, {Thomas N.} and Schmitz, {Joern E.} and Rodrigo, {Allen G.} and Permar, {Sallie R.}",

year = "2013",

doi = "10.1128/JVI.01643-13",

language = "English",

volume = "87",

pages = "11292--11299",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "20",

}

TY - JOUR

T1 - Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys

AU - Ho, Carrie

AU - Wu, Steven

AU - Amos, Joshua D.

AU - Colvin, Lisa

AU - Smith, Shannon D.

AU - Wilks, Andrew B.

AU - DeMarco, Todd

AU - Brinkley, Christie

AU - Denny, Thomas N.

AU - Schmitz, Joern E.

AU - Rodrigo, Allen G.

AU - Permar, Sallie R.

PY - 2013

Y1 - 2013

N2 - Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

AB - Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not persist longitudinally.

UR - http://www.scopus.com/inward/record.url?scp=84886887750&partnerID=8YFLogxK

U2 - 10.1128/JVI.01643-13

DO - 10.1128/JVI.01643-13

M3 - Article

SN - 0022-538X

VL - 87

SP - 11292

EP - 11299

JO - Journal of Virology

JF - Journal of Virology

IS - 20

ER -

Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys

Abstract

Access to Document

Other files and links

Fingerprint

Cite this