Transition metal-promoted arylation: An emerging strategy for protein bioconjugation

Lara R. Malins*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Transition metal-mediated arylation chemistry is emerging as a powerful tool for the selective modification of native peptides and proteins, providing new opportunities in the field of bioconjugation. This highlight paper will summarize recent methodologies for the regio- and chemoselective arylation of select proteinogenic side chains and backbone amide N-H bonds within unprotected peptides and proteins. The importance of the metal-ligand complex in achieving tunable selectivity and the inherent benefits of arylation as a mode of covalent protein modification will be highlighted.

Original languageEnglish
Pages (from-to)1360-1364
Number of pages5
JournalAustralian Journal of Chemistry
Issue number12
Publication statusPublished - 2016
Externally publishedYes


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