Transport properties of the host cell membrane

Kiaran Kirk*, Henry M. Staines, Rowena E. Martin, Kevin J. Saliba

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    25 Citations (Scopus)

    Abstract

    The malaria-infected erythrocyte shows an increased permeability to a wide range of solutes. The increase is mediated in part by parasite-induced new permeation pathways (NPP) and in part (for some solutes, under some conditions) by increased activity of endogenous transporters. The NPP provide the major route for the influx into the infected cell of a number of essential nutrients, but although the functional characteristics of these pathways are understood in some detail, they are yet to be identified at a molecular level. Lucifer yellow, a fluorescent anion, is taken up by malaria-infected erythrocytes to a much greater extent than uninfected erythrocytes via a pathway that differs in its pharmacological characteristics from the NPP. The nature, origin and location of this pathway remain to be established.

    Original languageEnglish
    Title of host publicationTransport and Trafficking in the Malaria-Infected Erythrocyte
    Pages55-73
    Number of pages19
    Volume226
    Publication statusPublished - 1999

    Publication series

    NameNovartis Foundation Symposium
    PublisherNovartis Foundation
    ISSN (Print)1528-2511

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