Abstract
Options for treatment of elderly patients with multiple myeloma have expanded substantially following the development of immunomodulatory drugs (IMiD), proteasome inhibitors and with enhancement in safety of high-dose therapy and autologous stem cell transplant (HDT + ASCT). The recognition of biological heterogeneity among elderly patients has made delivery of therapy more challenging. An individualised approach to treatment selection is recommended in an era in which highly efficacious treatment options are available for transplant-ineligible patients. Here, we summarise recommendations for patients who are considered unsuitable for HDT + ASCT, including pretreatment considerations, and induction, maintenance and supportive care therapies.
Original language | English |
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Pages (from-to) | 335-343 |
Number of pages | 9 |
Journal | Internal Medicine Journal |
Volume | 45 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Mar 2015 |