“TREXIT 2020”: why the time to abandon transrectal prostate biopsy starts now

Jeremy Grummet*, Michael A. Gorin, Rick Popert, Tim O’Brien, Alastair D. Lamb, Boris Hadaschik, Jan Philipp Radtke, Florian Wagenlehner, Eduard Baco, Caroline M. Moore, Mark Emberton, Arvin K. George, John W. Davis, Richard J. Szabo, Roger Buckley, Andrew Loblaw, Matthew Allaway, Christof Kastner, Erik Briers, Peter L. RoyceMark Frydenberg, Declan G. Murphy, Henry H. Woo

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

71 Citations (Scopus)


In 1847, 20 years before germ theory was popularised by Louis Pasteur, the Hungarian physician Ignaz Semmelweis famously reduced maternal mortality from post-partum sepsis from 16 to 1% simply by encouraging hand hygiene among his peers [1]. Despite the evidence, many physicians of the day were offended by the assertion that they themselves may be the cause of patient deaths and rejected Semmelweiss life-saving advice. Aged just 47, he suffered a nervous breakdown, was committed to an asylum and died within 2 weeks, ironically and tragically, from a gangrenous wound. Like Semmelweis, urologists today have the opportunity to nearly eliminate infections we cause by performing transrectal (TR) prostate biopsy and switch instead to the clean transperineal (TP) approacha process our co-authors at Guys Hospital in London, UK, have opportunistically dubbed TRexit [2, 3].
Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalProstate Cancer and Prostatic Diseases
Issue number1
Publication statusPublished - 1 Mar 2020
Externally publishedYes


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