TY - JOUR
T1 - Trityl chloride as an efficient organic catalyst for one-pot, five-component and diastereoselective synthesis of highly substituted piperidines
AU - Sajadikhah, Seyed Sajad
AU - Hazeri, Nourallah
AU - Maghsoodlou, Malek Taher
AU - Habibi-Khorassani, Sayyed Mostafa
AU - Willis, Anthony C.
PY - 2014/2
Y1 - 2014/2
N2 - Trityl chloride is used as an efficient organic catalyst for the one-pot, five-component and diastereoselective synthesis of highly substituted piperidines by means of reaction between aromatic aldehydes, amines and β-ketoesters in methanol at 50 C. The structure as well as relative stereochemistry of products was confirmed by single X-ray crystallographic analysis. This homogeneous catalyst procedure includes some important aspects like the easy work-up, diastereoselectivity, simple and readily available precursors, inexpensive catalyst, relatively short reaction time, and good to high yields. Graphical abstract: [Figure not available: see fulltext.]
AB - Trityl chloride is used as an efficient organic catalyst for the one-pot, five-component and diastereoselective synthesis of highly substituted piperidines by means of reaction between aromatic aldehydes, amines and β-ketoesters in methanol at 50 C. The structure as well as relative stereochemistry of products was confirmed by single X-ray crystallographic analysis. This homogeneous catalyst procedure includes some important aspects like the easy work-up, diastereoselectivity, simple and readily available precursors, inexpensive catalyst, relatively short reaction time, and good to high yields. Graphical abstract: [Figure not available: see fulltext.]
KW - Aldehyde
KW - Amine
KW - Piperidine
KW - Trityl chloride
KW - β-Ketoester
UR - http://www.scopus.com/inward/record.url?scp=84895060726&partnerID=8YFLogxK
U2 - 10.1007/s11164-012-0997-8
DO - 10.1007/s11164-012-0997-8
M3 - Article
SN - 0922-6168
VL - 40
SP - 723
EP - 736
JO - Research on Chemical Intermediates
JF - Research on Chemical Intermediates
IS - 2
ER -