Trityl chloride as an efficient organic catalyst for one-pot, five-component and diastereoselective synthesis of highly substituted piperidines

Seyed Sajad Sajadikhah, Nourallah Hazeri*, Malek Taher Maghsoodlou, Sayyed Mostafa Habibi-Khorassani, Anthony C. Willis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    31 Citations (Scopus)

    Abstract

    Trityl chloride is used as an efficient organic catalyst for the one-pot, five-component and diastereoselective synthesis of highly substituted piperidines by means of reaction between aromatic aldehydes, amines and β-ketoesters in methanol at 50 C. The structure as well as relative stereochemistry of products was confirmed by single X-ray crystallographic analysis. This homogeneous catalyst procedure includes some important aspects like the easy work-up, diastereoselectivity, simple and readily available precursors, inexpensive catalyst, relatively short reaction time, and good to high yields. Graphical abstract: [Figure not available: see fulltext.]

    Original languageEnglish
    Pages (from-to)723-736
    Number of pages14
    JournalResearch on Chemical Intermediates
    Volume40
    Issue number2
    DOIs
    Publication statusPublished - Feb 2014

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