Two rare cases of Epstein-Barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications

K. Subramaniam; M. Cherian; S. Jain; M. Latimer; M. Corbett; J. D'Rozario; P. Pavli

doi:10.1111/imj.12287

Two rare cases of Epstein-Barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications

K. Subramaniam^*, M. Cherian, S. Jain, M. Latimer, M. Corbett, J. D'Rozario, P. Pavli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The setting of chronic immunosuppression in inflammatory bowel disease (IBD) may promote the proliferation of Epstein-Barr virus-positive neoplastic clones. We report two rare cases of Epstein-Barr virus-associated lymphoproliferative disorder in IBD patients: one resembled lymphomatoid granulomatosis, and the other was a lymphoma resembling Hodgkin lymphoma. There are currently no guidelines for the prevention of lymphoproliferative disorder in IBD patients on immunosuppressive therapy.

Original language	English
Pages (from-to)	1339-1342
Number of pages	4
Journal	Internal Medicine Journal
Volume	43
Issue number	12
DOIs	https://doi.org/10.1111/imj.12287
Publication status	Published - Dec 2013

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10.1111/imj.12287

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title = "Two rare cases of Epstein-Barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications",

abstract = "The setting of chronic immunosuppression in inflammatory bowel disease (IBD) may promote the proliferation of Epstein-Barr virus-positive neoplastic clones. We report two rare cases of Epstein-Barr virus-associated lymphoproliferative disorder in IBD patients: one resembled lymphomatoid granulomatosis, and the other was a lymphoma resembling Hodgkin lymphoma. There are currently no guidelines for the prevention of lymphoproliferative disorder in IBD patients on immunosuppressive therapy.",

keywords = "Epstein-Barr virus, Immunosuppression, Inflammatory bowel disease, Lymphoma, Lymphoproliferative disorder",

author = "K. Subramaniam and M. Cherian and S. Jain and M. Latimer and M. Corbett and J. D'Rozario and P. Pavli",

year = "2013",

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AU - Subramaniam, K.

AU - Cherian, M.

AU - Jain, S.

AU - Latimer, M.

AU - Corbett, M.

AU - D'Rozario, J.

AU - Pavli, P.

PY - 2013/12

Y1 - 2013/12

N2 - The setting of chronic immunosuppression in inflammatory bowel disease (IBD) may promote the proliferation of Epstein-Barr virus-positive neoplastic clones. We report two rare cases of Epstein-Barr virus-associated lymphoproliferative disorder in IBD patients: one resembled lymphomatoid granulomatosis, and the other was a lymphoma resembling Hodgkin lymphoma. There are currently no guidelines for the prevention of lymphoproliferative disorder in IBD patients on immunosuppressive therapy.

AB - The setting of chronic immunosuppression in inflammatory bowel disease (IBD) may promote the proliferation of Epstein-Barr virus-positive neoplastic clones. We report two rare cases of Epstein-Barr virus-associated lymphoproliferative disorder in IBD patients: one resembled lymphomatoid granulomatosis, and the other was a lymphoma resembling Hodgkin lymphoma. There are currently no guidelines for the prevention of lymphoproliferative disorder in IBD patients on immunosuppressive therapy.

KW - Epstein-Barr virus

KW - Immunosuppression

KW - Inflammatory bowel disease

KW - Lymphoma

KW - Lymphoproliferative disorder

UR - https://www.scopus.com/pages/publications/84890163186

U2 - 10.1111/imj.12287

DO - 10.1111/imj.12287

M3 - Article

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SP - 1339

EP - 1342

JO - Internal Medicine Journal

JF - Internal Medicine Journal

IS - 12

ER -

Two rare cases of Epstein-Barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications

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