Two siblings with lethal pneumococcal meningitis in a family with a mutation in interleukin-1 receptor-associated kinase 4

Anselm Enders, Ulrich Pannicke, Reinhard Berner, Phillip Henneke, Klaus Radlinger, Klaus Schwarz, Stephan Ehl

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

We describe two siblings with one confirmed and one inferred homozygous base pair deletion in the gene for interleukin-1-related kinase 4 (IRAK-4) who died of pneumococcal meningitis at 2 and 14 months, respectively. Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections.

Original languageEnglish
Pages (from-to)698-700
Number of pages3
JournalJournal of Pediatrics
Volume145
Issue number5
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

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