Abstract
We describe two siblings with one confirmed and one inferred homozygous base pair deletion in the gene for interleukin-1-related kinase 4 (IRAK-4) who died of pneumococcal meningitis at 2 and 14 months, respectively. Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections.
Original language | English |
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Pages (from-to) | 698-700 |
Number of pages | 3 |
Journal | Journal of Pediatrics |
Volume | 145 |
Issue number | 5 |
DOIs | |
Publication status | Published - Nov 2004 |
Externally published | Yes |