TY - JOUR
T1 - Two-year changes in refractive error and related biometric factors in an adult Chinese population
AU - He, Mingguang
AU - Kong, Xiangbin
AU - Chen, Qianyun
AU - Zeng, Yangfa
AU - Huang, Yuanzhou
AU - Zhang, Jian
AU - Morgan, Ian G.
AU - Meltzer, Mirjam E.
AU - Jin, Ling
AU - Congdon, Nathan
PY - 2014/8
Y1 - 2014/8
N2 - IMPORTANCE This article provides, to our knowledge, the first longitudinal population-based data on refractive error (RE) in Chinese persons. OBJECTIVE To study cohort effects and changes associated with aging in REs among Chinese adults. DESIGN, SETTING, AND PARTICIPANTS A 2-year, longitudinal population-based cohort study was conducted in southern China. Participants, identified using cluster random sampling, included residents of Yuexiu District, Guangzhou, China, aged 35 years or older who had undergone no previous eye surgery. METHODS Participants underwent noncycloplegic automated refraction and keratometry in December 2008 and December 2010; in a random 50% sample of the participants, anterior segment ocular coherence tomography measurement of lens thickness, as well as measurement of axial length and anterior chamber depth by partial coherence laser interferometry, were performed. MAIN OUTCOMES AND MEASURES Two-year change in spherical equivalent refraction (RE), lens thickness, axial length, and anterior chamber depth in the right eye. RESULTS A total of 745 individuals underwent biometric testing in both 2008 and 2010 (2008 mean [SD] age, 52.2 [11.5] years; 53.7%women). Mean RE showed a 2-year hyperopic shift from -0.44 (2.21) to -0.31 (2.26) diopters (D) (difference, +0.13; 95%CI, 0.11 to 0.16). A consistent 2-year hyperopic shift of 0.09 to 0.22 D was observed among participants aged 35 to 64 years when stratifying by decade, suggesting that a substantial change in RE with aging may occur during this 30-year period. Cross-sectionally, RE increased only in the cohort younger than 50 years (0.11 D/y; 95%CI, 0.06 to 0.16). In the cross-sectional data, axial length decreased at -0.06 mm/y (95%CI, -0.09 to -0.04), although the 2-year change in axial length was positive and thus could not explain the cross-sectional difference. These latter results suggest a cohort effect, with greatermyopia developing among younger persons. CONCLUSIONS AND RELEVANCE This first Chinese population-based longitudinal study of RE provides evidence for both important longitudinal aging changes and cohort effects, most notably greatermyopia prevalence among younger persons.
AB - IMPORTANCE This article provides, to our knowledge, the first longitudinal population-based data on refractive error (RE) in Chinese persons. OBJECTIVE To study cohort effects and changes associated with aging in REs among Chinese adults. DESIGN, SETTING, AND PARTICIPANTS A 2-year, longitudinal population-based cohort study was conducted in southern China. Participants, identified using cluster random sampling, included residents of Yuexiu District, Guangzhou, China, aged 35 years or older who had undergone no previous eye surgery. METHODS Participants underwent noncycloplegic automated refraction and keratometry in December 2008 and December 2010; in a random 50% sample of the participants, anterior segment ocular coherence tomography measurement of lens thickness, as well as measurement of axial length and anterior chamber depth by partial coherence laser interferometry, were performed. MAIN OUTCOMES AND MEASURES Two-year change in spherical equivalent refraction (RE), lens thickness, axial length, and anterior chamber depth in the right eye. RESULTS A total of 745 individuals underwent biometric testing in both 2008 and 2010 (2008 mean [SD] age, 52.2 [11.5] years; 53.7%women). Mean RE showed a 2-year hyperopic shift from -0.44 (2.21) to -0.31 (2.26) diopters (D) (difference, +0.13; 95%CI, 0.11 to 0.16). A consistent 2-year hyperopic shift of 0.09 to 0.22 D was observed among participants aged 35 to 64 years when stratifying by decade, suggesting that a substantial change in RE with aging may occur during this 30-year period. Cross-sectionally, RE increased only in the cohort younger than 50 years (0.11 D/y; 95%CI, 0.06 to 0.16). In the cross-sectional data, axial length decreased at -0.06 mm/y (95%CI, -0.09 to -0.04), although the 2-year change in axial length was positive and thus could not explain the cross-sectional difference. These latter results suggest a cohort effect, with greatermyopia developing among younger persons. CONCLUSIONS AND RELEVANCE This first Chinese population-based longitudinal study of RE provides evidence for both important longitudinal aging changes and cohort effects, most notably greatermyopia prevalence among younger persons.
UR - http://www.scopus.com/inward/record.url?scp=84907352728&partnerID=8YFLogxK
U2 - 10.1001/jamaophthalmol.2014.1011
DO - 10.1001/jamaophthalmol.2014.1011
M3 - Article
SN - 2168-6165
VL - 132
SP - 978
EP - 984
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
IS - 8
ER -