Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Rajiv Kumar; Patrick T. Bunn; Siddharth Sankar Singh; Susanna S. Ng; Marcela Montes de Oca; Fabian De Labastida Rivera; Shashi Bhushan Chauhan; Neetu Singh; Rebecca J. Faleiro; Chelsea L. Edwards; Teija C.M. Frame; Meru Sheel; Rebecca J. Austin; Steven W. Lane; Tobias Bald; Mark J. Smyth; Geoffrey R. Hill; Shannon E. Best; Ashraful Haque; Dillon Corvino; Nic Waddell; Lambross Koufariotis; Pamela Mukhopadhay; Madhukar Rai; Jaya Chakravarty; Om Prakash Singh; David Sacks; Susanne Nylen; Jude Uzonna; Shyam Sundar; Christian R. Engwerda

doi:10.1016/j.celrep.2020.01.099

Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Rajiv Kumar^*, Patrick T. Bunn, Siddharth Sankar Singh, Susanna S. Ng, Marcela Montes de Oca, Fabian De Labastida Rivera, Shashi Bhushan Chauhan, Neetu Singh, Rebecca J. Faleiro, Chelsea L. Edwards, Teija C.M. Frame, Meru Sheel, Rebecca J. Austin, Steven W. Lane, Tobias Bald, Mark J. Smyth, Geoffrey R. Hill, Shannon E. Best, Ashraful Haque, Dillon CorvinoNic Waddell, Lambross Koufariotis, Pamela Mukhopadhay, Madhukar Rai, Jaya Chakravarty, Om Prakash Singh, David Sacks, Susanne Nylen, Jude Uzonna, Shyam Sundar, Christian R. Engwerda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

CD4⁺ T cells are critical for control of intracellular parasites such as Leishmania donovani. Kumar et al. show that type I interferons (IFNs) suppress Th1 cells and promote IL-10-producing CD4⁺ T cells during visceral leishmaniasis (VL). Thus, manipulation of type I IFN signaling may improve disease outcome in VL patients.

Original language	English
Pages (from-to)	2512-2525.e9
Journal	Cell Reports
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2020.01.099
Publication status	Published - 25 Feb 2020

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10.1016/j.celrep.2020.01.099

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Kumar, R., Bunn, P. T., Singh, S. S., Ng, S. S., Montes de Oca, M., De Labastida Rivera, F., Chauhan, S. B., Singh, N., Faleiro, R. J., Edwards, C. L., Frame, T. C. M., Sheel, M., Austin, R. J., Lane, S. W., Bald, T., Smyth, M. J., Hill, G. R., Best, S. E., Haque, A., ... Engwerda, C. R. (2020). Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis. Cell Reports, 30(8), 2512-2525.e9. https://doi.org/10.1016/j.celrep.2020.01.099

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title = "Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis",

abstract = "CD4+ T cells are critical for control of intracellular parasites such as Leishmania donovani. Kumar et al. show that type I interferons (IFNs) suppress Th1 cells and promote IL-10-producing CD4+ T cells during visceral leishmaniasis (VL). Thus, manipulation of type I IFN signaling may improve disease outcome in VL patients.",

keywords = "CD4 T cells, type I interferons, visceral leishmaniasis",

author = "Rajiv Kumar and Bunn, {Patrick T.} and Singh, {Siddharth Sankar} and Ng, {Susanna S.} and {Montes de Oca}, Marcela and {De Labastida Rivera}, Fabian and Chauhan, {Shashi Bhushan} and Neetu Singh and Faleiro, {Rebecca J.} and Edwards, {Chelsea L.} and Frame, {Teija C.M.} and Meru Sheel and Austin, {Rebecca J.} and Lane, {Steven W.} and Tobias Bald and Smyth, {Mark J.} and Hill, {Geoffrey R.} and Best, {Shannon E.} and Ashraful Haque and Dillon Corvino and Nic Waddell and Lambross Koufariotis and Pamela Mukhopadhay and Madhukar Rai and Jaya Chakravarty and Singh, {Om Prakash} and David Sacks and Susanne Nylen and Jude Uzonna and Shyam Sundar and Engwerda, {Christian R.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = feb,

day = "25",

doi = "10.1016/j.celrep.2020.01.099",

language = "English",

volume = "30",

pages = "2512--2525.e9",

journal = "Cell Reports",

issn = "2211-1247",

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Kumar, R, Bunn, PT, Singh, SS, Ng, SS, Montes de Oca, M, De Labastida Rivera, F, Chauhan, SB, Singh, N, Faleiro, RJ, Edwards, CL, Frame, TCM, Sheel, M, Austin, RJ, Lane, SW, Bald, T, Smyth, MJ, Hill, GR, Best, SE, Haque, A, Corvino, D, Waddell, N, Koufariotis, L, Mukhopadhay, P, Rai, M, Chakravarty, J, Singh, OP, Sacks, D, Nylen, S, Uzonna, J, Sundar, S & Engwerda, CR 2020, 'Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis', Cell Reports, vol. 30, no. 8, pp. 2512-2525.e9. https://doi.org/10.1016/j.celrep.2020.01.099

TY - JOUR

T1 - Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

AU - Kumar, Rajiv

AU - Bunn, Patrick T.

AU - Singh, Siddharth Sankar

AU - Ng, Susanna S.

AU - Montes de Oca, Marcela

AU - De Labastida Rivera, Fabian

AU - Chauhan, Shashi Bhushan

AU - Singh, Neetu

AU - Faleiro, Rebecca J.

AU - Edwards, Chelsea L.

AU - Frame, Teija C.M.

AU - Sheel, Meru

AU - Austin, Rebecca J.

AU - Lane, Steven W.

AU - Bald, Tobias

AU - Smyth, Mark J.

AU - Hill, Geoffrey R.

AU - Best, Shannon E.

AU - Haque, Ashraful

AU - Corvino, Dillon

AU - Waddell, Nic

AU - Koufariotis, Lambross

AU - Mukhopadhay, Pamela

AU - Rai, Madhukar

AU - Chakravarty, Jaya

AU - Singh, Om Prakash

AU - Sacks, David

AU - Nylen, Susanne

AU - Uzonna, Jude

AU - Sundar, Shyam

AU - Engwerda, Christian R.

PY - 2020/2/25

Y1 - 2020/2/25

N2 - CD4+ T cells are critical for control of intracellular parasites such as Leishmania donovani. Kumar et al. show that type I interferons (IFNs) suppress Th1 cells and promote IL-10-producing CD4+ T cells during visceral leishmaniasis (VL). Thus, manipulation of type I IFN signaling may improve disease outcome in VL patients.

AB - CD4+ T cells are critical for control of intracellular parasites such as Leishmania donovani. Kumar et al. show that type I interferons (IFNs) suppress Th1 cells and promote IL-10-producing CD4+ T cells during visceral leishmaniasis (VL). Thus, manipulation of type I IFN signaling may improve disease outcome in VL patients.

KW - CD4 T cells

KW - type I interferons

KW - visceral leishmaniasis

UR - http://www.scopus.com/inward/record.url?scp=85079747849&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.01.099

DO - 10.1016/j.celrep.2020.01.099

M3 - Article

SN - 2211-1247

VL - 30

SP - 2512-2525.e9

JO - Cell Reports

JF - Cell Reports

IS - 8

ER -

Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

Abstract

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