@inproceedings{76b855381b784d5abda06f8e3980a686,
title = "Unsupervised learning for exploring MALDI imaging mass spectrometry 'omics' data",
abstract = "Matrix Assisted Laser Desorption Ionization-Imaging Mass Spectrometry (MALDI-IMS) is an emerging data acquisition technology in biological research. It has gained its popularity in 'omics' sciences because of its ability to explore the spatial distributions of various bio-molecules in detail. The sheer volume of data generated through this technology and the often limited a priori knowledge about the molecular compositions of biological samples, call for efficient data analysis methods. In this paper, first we review the available computational methods for analyzing the high-dimensional imaging datasets highlighting their advantages and limitations. Then, we propose a more recent unsupervised method as a means of exploring MALDI-IMS data and demonstrate its competency by extracting hidden significant spatial distribution patterns of a rat brain imaging dataset. Finally, we explain the potential future advances of 'omics' research associated with MALDI-IMS and the foreseeable challenges in analyzing the resultant data.",
keywords = "Data Analysis, Imaging, MALDI, Metabolomics, Proteomics, Unsupervised",
author = "Wijetunge, {Chalini D.} and Isaam Saeed and Halgamuge, {Saman K.} and Berin Boughton and Ute Roessner",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 7th International Conference on Information and Automation for Sustainability, ICIAfS 2014 ; Conference date: 22-12-2014 Through 24-12-2014",
year = "2014",
month = mar,
day = "26",
doi = "10.1109/ICIAFS.2014.7069634",
language = "English",
series = "2014 7th International Conference on Information and Automation for Sustainability: {"}Sharpening the Future with Sustainable Technology{"}, ICIAfS 2014",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2014 7th International Conference on Information and Automation for Sustainability",
address = "United States",
}