TY - JOUR
T1 - Unveiling synaptic plasticity
T2 - A new graphical and analytical approach
AU - Clements, John D.
AU - Silve, R. Angus
PY - 2000/3/1
Y1 - 2000/3/1
N2 - Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic site. This article describes a new approach that, in its simplest form, can identify the site of expression by direct graphical means. A more-sophisticated form of the technique can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength. Copyright (C) 2000 Elsevier Science Ltd.
AB - Short-term synaptic plasticity has a key role in information processing in the CNS, whereas memories can be formed through long-lasting changes in synaptic strength. Despite the importance of these phenomena, it remains difficult to determine whether a synaptic modulation is expressed at a presynaptic or postsynaptic site. This article describes a new approach that, in its simplest form, can identify the site of expression by direct graphical means. A more-sophisticated form of the technique can quantify functional synaptic properties and determine which of these properties is altered following a modulation of synaptic strength. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034160151&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(99)01520-9
DO - 10.1016/S0166-2236(99)01520-9
M3 - Review article
SN - 0166-2236
VL - 23
SP - 105
EP - 113
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 3
ER -