Use of murine mutants to study glycine receptor function

Robert J. Callister*, P. R. Schofield, P. Sah

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    1. The accompanying articles in this symposium describe several different approaches used to examine the function of glycine and GABA receptors, including pharmacology and neurochemistry, permeability and agonist-binding approaches, the use of mutated recombinant receptors and monoclonal antibody staining to examine receptor distribution on neurons. 2. The present review focuses on the use of another, quite different, approach: the use of murine mutants, spasmodic and spastic, to study the function of native glycine receptors at synaptic connections within the central nervous system.

    Original languageEnglish
    Pages (from-to)929-931
    Number of pages3
    JournalClinical and Experimental Pharmacology and Physiology
    Volume26
    Issue number11
    DOIs
    Publication statusPublished - 1999

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