Using 2H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE

Philip Norcott; Michael J. Burns; Peter J. Rayner; Ryan E. Mewis; Simon B. Duckett

doi:10.1002/mrc.4703

Using ²H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE

Philip Norcott, Michael J. Burns, Peter J. Rayner, Ryan E. Mewis, Simon B. Duckett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

By introducing a range of ²H labels into pyridine and the para-substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T₁ relaxation for the remaining ¹H nuclei are increased and show how this leads to a concomitant increase in the level of ¹H and ¹³C hyperpolarization that can ultimately be detected.

Original language	English
Pages (from-to)	663-671
Number of pages	9
Journal	Magnetic Resonance in Chemistry
Volume	56
Issue number	7
DOIs	https://doi.org/10.1002/mrc.4703
Publication status	Published - Jul 2018
Externally published	Yes

Access to Document

10.1002/mrc.4703

Cite this

@article{adfb485248fe463b9ee9c4107753596b,

title = "Using 2H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE",

abstract = "By introducing a range of 2H labels into pyridine and the para-substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.",

keywords = "NMR, SABRE, hyperpolarisation, parahydrogen",

author = "Philip Norcott and Burns, {Michael J.} and Rayner, {Peter J.} and Mewis, {Ryan E.} and Duckett, {Simon B.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.",

year = "2018",

month = jul,

doi = "10.1002/mrc.4703",

language = "English",

volume = "56",

pages = "663--671",

journal = "Magnetic Resonance in Chemistry",

issn = "0749-1581",

publisher = "John Wiley & Sons Ltd.",

number = "7",

}

TY - JOUR

T1 - Using 2H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE

AU - Norcott, Philip

AU - Burns, Michael J.

AU - Rayner, Peter J.

AU - Mewis, Ryan E.

AU - Duckett, Simon B.

PY - 2018/7

Y1 - 2018/7

N2 - By introducing a range of 2H labels into pyridine and the para-substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.

AB - By introducing a range of 2H labels into pyridine and the para-substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.

KW - NMR

KW - SABRE

KW - hyperpolarisation

KW - parahydrogen

UR - http://www.scopus.com/inward/record.url?scp=85041048830&partnerID=8YFLogxK

U2 - 10.1002/mrc.4703

DO - 10.1002/mrc.4703

M3 - Article

SN - 0749-1581

VL - 56

SP - 663

EP - 671

JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

IS - 7

ER -

Using ²H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE

Abstract

Access to Document

Other files and links

Fingerprint

Cite this