TY - JOUR
T1 - Vitamin A levels in patients with CF are influenced by the inflammatory response
AU - Greer, Ristan M.
AU - Buntain, Helen M.
AU - Lewindon, Peter J.
AU - Wainwright, Claire E.
AU - Potter, Julia M.
AU - Wong, Joseph C.
AU - Francis, Paul W.
AU - Batch, Jennifer A.
AU - Bell, Scott C.
PY - 2004/8
Y1 - 2004/8
N2 - Background: Serum vitamin A, normally depressed in inflammatory conditions, is frequently low in people with CF. Vitamin A is important in respiratory epithelial regeneration and repair. We hypothesised that serum vitamin A would be associated with inflammation and disease severity. Methods: Serum vitamin A (as retinol), C-reactive protein (CRP), vitamin E, 25-hydroxy vitamin D (25OHD), 1,25-dihydroxy vitamin D (1,25(OH)2D), weight, and lumbar spine bone mineral density (LSBMD) were measured in 138 subjects with CF (5-56 years) and 138 control subjects (5-48 years). FEV1, presence of CF liver disease (CFLD) and hospital admissions were recorded in those with CF. Results: Serum vitamin A level was lower in CF subjects than in controls (mean, 95% CI: 1.29, 1.0-1.37 vs. 1.80, 1.7-1.87 μmol/l, p <0.0001), and inversely correlated with CRP (r s=-0.37, p <0.0001). CF subjects with low vitamin A (45%) level had poorer FEV1, weight z -score, LSBMD z -score, and higher CRP compared with those with normal levels. In the CF group CRP, vitamin E, 1,25(OH)2D, presence of CFLD, admissions, and age were associated with vitamin A level. Conclusions: Serum vitamin A is negatively associated with CRP in subjects with CF, consistent with normal population studies. It is important to distinguish between low serum vitamin A associated with the inflammatory response and that due to poor nutritional stores. The role of vitamin A in CF warrants further study, in the contexts both of chronic recurrent inflammatory disease and acute pulmonary exacerbation.
AB - Background: Serum vitamin A, normally depressed in inflammatory conditions, is frequently low in people with CF. Vitamin A is important in respiratory epithelial regeneration and repair. We hypothesised that serum vitamin A would be associated with inflammation and disease severity. Methods: Serum vitamin A (as retinol), C-reactive protein (CRP), vitamin E, 25-hydroxy vitamin D (25OHD), 1,25-dihydroxy vitamin D (1,25(OH)2D), weight, and lumbar spine bone mineral density (LSBMD) were measured in 138 subjects with CF (5-56 years) and 138 control subjects (5-48 years). FEV1, presence of CF liver disease (CFLD) and hospital admissions were recorded in those with CF. Results: Serum vitamin A level was lower in CF subjects than in controls (mean, 95% CI: 1.29, 1.0-1.37 vs. 1.80, 1.7-1.87 μmol/l, p <0.0001), and inversely correlated with CRP (r s=-0.37, p <0.0001). CF subjects with low vitamin A (45%) level had poorer FEV1, weight z -score, LSBMD z -score, and higher CRP compared with those with normal levels. In the CF group CRP, vitamin E, 1,25(OH)2D, presence of CFLD, admissions, and age were associated with vitamin A level. Conclusions: Serum vitamin A is negatively associated with CRP in subjects with CF, consistent with normal population studies. It is important to distinguish between low serum vitamin A associated with the inflammatory response and that due to poor nutritional stores. The role of vitamin A in CF warrants further study, in the contexts both of chronic recurrent inflammatory disease and acute pulmonary exacerbation.
KW - C-reactive protein
KW - Cystic fibrosis
KW - Inflammation
KW - Retinol
UR - http://www.scopus.com/inward/record.url?scp=4444353741&partnerID=8YFLogxK
U2 - 10.1016/j.jcf.2004.04.003
DO - 10.1016/j.jcf.2004.04.003
M3 - Article
SN - 1569-1993
VL - 3
SP - 143
EP - 149
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
IS - 3
ER -