Abstract
Exposure of a human lung epithelial cancer cell-line to hypo-osmotic media led to a marked increase in the rate of efflux from the cells of taurine, a non-essential sulfonic amino acid. The osmotically-activated taurine efflux was inhibited by a range of known Cl- channel blockers, the most potent of which were NPPB and 1,9-dideoxyforskolin. These reagents were similarly effective at inhibiting the osmotically-activated efflux of I-, a known substrate of volume-activated Cl- channels. The results are consistent with the hypothesis that volume-regulatory taurine release from these cells is mediated by a volume-activated Cl- channel.
Original language | English |
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Pages (from-to) | 153-158 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 336 |
Issue number | 1 |
DOIs | |
Publication status | Published - 20 Dec 1993 |
Externally published | Yes |