Weird animal genomes and the evolution of human sex chromosomes

Jennifer Graves

    Research output: Contribution to journalMeeting Abstractpeer-review

    Abstract

    Humans, mice, and even kangaroos have an XX female:XY male system of sex determination, in which the Y harbors a male-dominant sex-determining gene SRY. Birds have the opposite, ZZ males and ZW females, and may use a dosage-sensitive Z-borne gene. Other reptiles have genetic sex but no visible sex chromosomes, or determine sex by temperature of egg incubation. How can we make sense of so much variation? How do systems change in evolution? Studies of some unlikely animalsplatypus and dragon lizards, frogs and fishconfirm that evolutionary transitions have occurred between TSD and GSD systems, between XY and ZW systems, and even between male and female heterogametic systems. Here I explore nonmodel systems that offer some new perspectives on some venerable questions of sex and sex chromosomes.
    Original languageEnglish
    Pages (from-to)15
    JournalHormone Research
    Volume42
    Publication statusPublished - 2009
    EventLWPES/ESPE 8th Joint Meeting Global Care in Pediatric Endocrinology in collaboration with APEG, APPES, JSPE and SLEP - New York, United States
    Duration: 1 Jan 2009 → …
    https://www.karger.com/Article/Abstract/239668

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