Weird animal genomes and the evolution of vertebrate sex and sex chromosomes

Jennifer A. Marshall Graves

    Research output: Contribution to journalReview articlepeer-review

    209 Citations (Scopus)


    Humans, mice, and even kangaroos have an XX female:XY male system of sex determination, in which the Y harbors a male-dominant sex-determining gene SRY. Birds have the opposite, ZZ males and ZW females, and may use a dosage-sensitive Z-borne gene. Other reptiles have genetic sex but no visible sex chromosomes, or determine sex by temperature of egg incubation. How can we make sense of so much variation? How do systems change in evolution? Studies of some unlikely animals - platypus and dragon lizards, frogs and fish - confirm that evolutionary transitions have occurred between TSD and GSD systems, between XY and ZW systems, and even between male and female heterogametic systems. Here I explore nonmodel systems that offer some new perspectives on some venerable questions of sex and sex chromosomes.

    Original languageEnglish
    Pages (from-to)565-586
    Number of pages22
    JournalAnnual Review of Genetics
    Publication statusPublished - 2008


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