White matter hyperintensities and within-person variability in community-dwelling adults aged 60-64 years

David Bunce*, Kaarin J. Anstey, Helen Christensen, Keith Dear, Wei Wen, Perminder Sachdev

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    99 Citations (Scopus)

    Abstract

    Estimates of white matter hyperintensities (WMH) derived from T2-weighted MRI were investigated in relation to cognitive performance in 469 healthy community-dwelling adults aged 60-64 years. Frontal lobe WMH but not WMH from other brain regions (temporal, parietal, and occipital lobes, anterior and posterior horn, periventricular body) were associated with elevated within-person reaction time (RT) variability (trial to trial fluctuations in RT performance) but not performance on several other cognitive tasks including psychomotor speed, memory, and global cognition. The findings are consistent with the view that elevated within-person variability is related to neurobiological disturbance, and that attentional mechanisms supported by the frontal cortex play a key role in this type of variability.

    Original languageEnglish
    Pages (from-to)2009-2015
    Number of pages7
    JournalNeuropsychologia
    Volume45
    Issue number9
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    Dive into the research topics of 'White matter hyperintensities and within-person variability in community-dwelling adults aged 60-64 years'. Together they form a unique fingerprint.

    Cite this