Without mechanisms, theories and models in insect epigenetics remain a black box

Ryszard Maleszka; Robert Kucharski

doi:10.1016/j.tig.2022.05.004

Without mechanisms, theories and models in insect epigenetics remain a black box

Ryszard Maleszka^*, Robert Kucharski

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

8 Citations (Scopus)

Abstract

Insect epigenetics must confront the remarkable diversity of epigenomic systems in various lineages and use mechanistic approaches to move beyond vague functional explanations based on predictions and inferences. To accelerate progress, what is required now is a convergence of genomic data with biochemical and single-cell-type analyses in selected species representing contrasting evolutionary solutions in epigenetics.

Original language	English
Pages (from-to)	1108-1111
Number of pages	4
Journal	Trends in Genetics
Volume	38
Issue number	11
DOIs	https://doi.org/10.1016/j.tig.2022.05.004
Publication status	Published - Nov 2022

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10.1016/j.tig.2022.05.004

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title = "Without mechanisms, theories and models in insect epigenetics remain a black box",

abstract = "Insect epigenetics must confront the remarkable diversity of epigenomic systems in various lineages and use mechanistic approaches to move beyond vague functional explanations based on predictions and inferences. To accelerate progress, what is required now is a convergence of genomic data with biochemical and single-cell-type analyses in selected species representing contrasting evolutionary solutions in epigenetics.",

keywords = "DNMT, eutelic species, honey bee, imaginal discs, nematodes, phenotypic plasticity",

author = "Ryszard Maleszka and Robert Kucharski",

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AU - Maleszka, Ryszard

AU - Kucharski, Robert

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N2 - Insect epigenetics must confront the remarkable diversity of epigenomic systems in various lineages and use mechanistic approaches to move beyond vague functional explanations based on predictions and inferences. To accelerate progress, what is required now is a convergence of genomic data with biochemical and single-cell-type analyses in selected species representing contrasting evolutionary solutions in epigenetics.

AB - Insect epigenetics must confront the remarkable diversity of epigenomic systems in various lineages and use mechanistic approaches to move beyond vague functional explanations based on predictions and inferences. To accelerate progress, what is required now is a convergence of genomic data with biochemical and single-cell-type analyses in selected species representing contrasting evolutionary solutions in epigenetics.

KW - DNMT

KW - eutelic species

KW - honey bee

KW - imaginal discs

KW - nematodes

KW - phenotypic plasticity

UR - http://www.scopus.com/inward/record.url?scp=85130537017&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2022.05.004

DO - 10.1016/j.tig.2022.05.004

M3 - Short survey

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SP - 1108

EP - 1111

JO - Trends in Genetics

JF - Trends in Genetics

IS - 11

ER -

Without mechanisms, theories and models in insect epigenetics remain a black box

Abstract

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