World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010

Arie H. Havelaar; Martyn D. Kirk; Paul R. Torgerson; Herman J. Gibb; Tine Hald; Robin J. Lake; Nicolas Praet; David C. Bellinger; Nilanthi R. de Silva; Neyla Gargouri; Niko Speybroeck; Amy Cawthorne; Colin Mathers; Claudia Stein; Frederick J. Angulo; Brecht Devleesschauwer; Gabriel O. Adegoke; Reza Afshari; Deena Alasfoor; Janis Baines; Kalpana Balakrishnan; Wan Mansor Bin Hamza; Robert E. Black; P. Michael Bolger; Wanpen Chaicumpa; Alejandro Cravioto; Dörte Döpfer; John E. Ehiri; Aamir Fazil; Catterina Ferreccio; Eric M. Fèvre; Gillian Hall; Fumiko Kasuga; Karen H. Keddy; Claudio F. Lanata; Haicho Lei; Xiumei Liu; Ben Manyindo; George Nasinyama; Pierre Ongolo-Zogo; John I. Pitt; Mohammad B. Rokni; Banchob Sripa; Rolaf van Leeuwen; Philippe Verger; Arve Lee Willingham; Xiao Nong Zhou; Willy Aspinall; Robert Buchanan; Christine Budke; Marisa L. Caipo; Hélène Carabin; Dana Cole; Roger M. Cooke; John A. Crump; Fadi El-Jardali; Christa Fischer-Walker; Thomas Fürst; Juanita A. Haagsma; Aron J. Hall; Olga Henao; Sandra Hoffmann; Helen Jensen; Nasreen Jessani; Marion P.G. Koopmans; Myron M. Levine; Charline Maertens de Noordhout; Shannon Majowicz; Scott A. McDonald; Sara Pires; Elaine Scallan; Banchob Sripa; M. Kate Thomas; Linda Verhoef; Felicia Wu; Marco Zeilmaker

doi:10.1371/journal.pmed.1001923

World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010

Arie H. Havelaar^*, Martyn D. Kirk, Paul R. Torgerson, Herman J. Gibb, Tine Hald, Robin J. Lake, Nicolas Praet, David C. Bellinger, Nilanthi R. de Silva, Neyla Gargouri, Niko Speybroeck, Amy Cawthorne, Colin Mathers, Claudia Stein, Frederick J. Angulo, Brecht Devleesschauwer, Gabriel O. Adegoke, Reza Afshari, Deena Alasfoor, Janis BainesKalpana Balakrishnan, Wan Mansor Bin Hamza, Robert E. Black, P. Michael Bolger, Wanpen Chaicumpa, Alejandro Cravioto, Dörte Döpfer, John E. Ehiri, Aamir Fazil, Catterina Ferreccio, Eric M. Fèvre, Gillian Hall, Fumiko Kasuga, Karen H. Keddy, Claudio F. Lanata, Haicho Lei, Xiumei Liu, Ben Manyindo, George Nasinyama, Pierre Ongolo-Zogo, John I. Pitt, Mohammad B. Rokni, Banchob Sripa, Rolaf van Leeuwen, Philippe Verger, Arve Lee Willingham, Xiao Nong Zhou, Willy Aspinall, Robert Buchanan, Christine Budke, Marisa L. Caipo, Hélène Carabin, Dana Cole, Roger M. Cooke, John A. Crump, Fadi El-Jardali, Christa Fischer-Walker, Thomas Fürst, Juanita A. Haagsma, Aron J. Hall, Olga Henao, Sandra Hoffmann, Helen Jensen, Nasreen Jessani, Marion P.G. Koopmans, Myron M. Levine, Charline Maertens de Noordhout, Shannon Majowicz, Scott A. McDonald, Sara Pires, Elaine Scallan, Banchob Sripa, M. Kate Thomas, Linda Verhoef, Felicia Wu, Marco Zeilmaker

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1277 Citations (Scopus)

Abstract

Illness and death from diseases caused by contaminated food are a constant threat to public health and a significant impediment to socio-economic development worldwide. To measure the global and regional burden of foodborne disease (FBD), the World Health Organization (WHO) established the Foodborne Disease Burden Epidemiology Reference Group (FERG), which here reports their first estimates of the incidence, mortality, and disease burden due to 31 foodborne hazards. We find that the global burden of FBD is comparable to those of the major infectious diseases, HIV/AIDS, malaria and tuberculosis. The most frequent causes of foodborne illness were diarrheal disease agents, particularly norovirus and Campylobacter spp. Diarrheal disease agents, especially non-typhoidal Salmonella enterica, were also responsible for the majority of deaths due to FBD. Other major causes of FBD deaths were Salmonella Typhi, Taenia solium and hepatitis A virus. The global burden of FBD caused by the 31 hazards in 2010 was 33 million Disability Adjusted Life Years (DALYs); children under five years old bore 40% of this burden. The 14 subregions, defined on the basis of child and adult mortality, had considerably different burdens of FBD, with the greatest falling on the subregions in Africa, followed by the subregions in South-East Asia and the Eastern Mediterranean D subregion. Some hazards, such as non-typhoidal S. enterica, were important causes of FBD in all regions of the world, whereas others, such as certain parasitic helminths, were highly localised. Thus, the burden of FBD is borne particularly by children under five years old–although they represent only 9% of the global population–and people living in low-income regions of the world. These estimates are conservative, i.e., underestimates rather than overestimates; further studies are needed to address the data gaps and limitations of the study. Nevertheless, all stakeholders can contribute to improvements in food safety throughout the food chain by incorporating these estimates into policy development at national and international levels.

Original language	English
Article number	e1001923
Journal	PLoS Medicine
Volume	12
Issue number	12
DOIs	https://doi.org/10.1371/journal.pmed.1001923
Publication status	Published - 2015

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10.1371/journal.pmed.1001923

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Havelaar, A. H., Kirk, M. D., Torgerson, P. R., Gibb, H. J., Hald, T., Lake, R. J., Praet, N., Bellinger, D. C., de Silva, N. R., Gargouri, N., Speybroeck, N., Cawthorne, A., Mathers, C., Stein, C., Angulo, F. J., Devleesschauwer, B., Adegoke, G. O., Afshari, R., Alasfoor, D., ... Zeilmaker, M. (2015). World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010. PLoS Medicine, 12(12), Article e1001923. https://doi.org/10.1371/journal.pmed.1001923

@article{bf0a4cf8d6de426cab625d654aa64ea2,

title = "World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010",

abstract = "Illness and death from diseases caused by contaminated food are a constant threat to public health and a significant impediment to socio-economic development worldwide. To measure the global and regional burden of foodborne disease (FBD), the World Health Organization (WHO) established the Foodborne Disease Burden Epidemiology Reference Group (FERG), which here reports their first estimates of the incidence, mortality, and disease burden due to 31 foodborne hazards. We find that the global burden of FBD is comparable to those of the major infectious diseases, HIV/AIDS, malaria and tuberculosis. The most frequent causes of foodborne illness were diarrheal disease agents, particularly norovirus and Campylobacter spp. Diarrheal disease agents, especially non-typhoidal Salmonella enterica, were also responsible for the majority of deaths due to FBD. Other major causes of FBD deaths were Salmonella Typhi, Taenia solium and hepatitis A virus. The global burden of FBD caused by the 31 hazards in 2010 was 33 million Disability Adjusted Life Years (DALYs); children under five years old bore 40% of this burden. The 14 subregions, defined on the basis of child and adult mortality, had considerably different burdens of FBD, with the greatest falling on the subregions in Africa, followed by the subregions in South-East Asia and the Eastern Mediterranean D subregion. Some hazards, such as non-typhoidal S. enterica, were important causes of FBD in all regions of the world, whereas others, such as certain parasitic helminths, were highly localised. Thus, the burden of FBD is borne particularly by children under five years old–although they represent only 9% of the global population–and people living in low-income regions of the world. These estimates are conservative, i.e., underestimates rather than overestimates; further studies are needed to address the data gaps and limitations of the study. Nevertheless, all stakeholders can contribute to improvements in food safety throughout the food chain by incorporating these estimates into policy development at national and international levels.",

author = "Havelaar, {Arie H.} and Kirk, {Martyn D.} and Torgerson, {Paul R.} and Gibb, {Herman J.} and Tine Hald and Lake, {Robin J.} and Nicolas Praet and Bellinger, {David C.} and {de Silva}, {Nilanthi R.} and Neyla Gargouri and Niko Speybroeck and Amy Cawthorne and Colin Mathers and Claudia Stein and Angulo, {Frederick J.} and Brecht Devleesschauwer and Adegoke, {Gabriel O.} and Reza Afshari and Deena Alasfoor and Janis Baines and Kalpana Balakrishnan and Hamza, {Wan Mansor Bin} and Black, {Robert E.} and Bolger, {P. Michael} and Wanpen Chaicumpa and Alejandro Cravioto and D{\"o}rte D{\"o}pfer and Ehiri, {John E.} and Aamir Fazil and Catterina Ferreccio and F{\`e}vre, {Eric M.} and Gillian Hall and Fumiko Kasuga and Keddy, {Karen H.} and Lanata, {Claudio F.} and Haicho Lei and Xiumei Liu and Ben Manyindo and George Nasinyama and Pierre Ongolo-Zogo and Pitt, {John I.} and Rokni, {Mohammad B.} and Banchob Sripa and {van Leeuwen}, Rolaf and Philippe Verger and Willingham, {Arve Lee} and Zhou, {Xiao Nong} and Willy Aspinall and Robert Buchanan and Christine Budke and Caipo, {Marisa L.} and H{\'e}l{\`e}ne Carabin and Dana Cole and Cooke, {Roger M.} and Crump, {John A.} and Fadi El-Jardali and Christa Fischer-Walker and Thomas F{\"u}rst and Haagsma, {Juanita A.} and Hall, {Aron J.} and Olga Henao and Sandra Hoffmann and Helen Jensen and Nasreen Jessani and Koopmans, {Marion P.G.} and Levine, {Myron M.} and {de Noordhout}, {Charline Maertens} and Shannon Majowicz and McDonald, {Scott A.} and Sara Pires and Elaine Scallan and Banchob Sripa and Thomas, {M. Kate} and Linda Verhoef and Felicia Wu and Marco Zeilmaker",

year = "2015",

doi = "10.1371/journal.pmed.1001923",

language = "English",

volume = "12",

journal = "PLoS Medicine",

issn = "1549-1277",

publisher = "Public Library of Science",

number = "12",

}

Havelaar, AH, Kirk, MD, Torgerson, PR, Gibb, HJ, Hald, T, Lake, RJ, Praet, N, Bellinger, DC, de Silva, NR, Gargouri, N, Speybroeck, N, Cawthorne, A, Mathers, C, Stein, C, Angulo, FJ, Devleesschauwer, B, Adegoke, GO, Afshari, R, Alasfoor, D, Baines, J, Balakrishnan, K, Hamza, WMB, Black, RE, Bolger, PM, Chaicumpa, W, Cravioto, A, Döpfer, D, Ehiri, JE, Fazil, A, Ferreccio, C, Fèvre, EM, Hall, G, Kasuga, F, Keddy, KH, Lanata, CF, Lei, H, Liu, X, Manyindo, B, Nasinyama, G, Ongolo-Zogo, P, Pitt, JI, Rokni, MB, Sripa, B, van Leeuwen, R, Verger, P, Willingham, AL, Zhou, XN, Aspinall, W, Buchanan, R, Budke, C, Caipo, ML, Carabin, H, Cole, D, Cooke, RM, Crump, JA, El-Jardali, F, Fischer-Walker, C, Fürst, T, Haagsma, JA, Hall, AJ, Henao, O, Hoffmann, S, Jensen, H, Jessani, N, Koopmans, MPG, Levine, MM, de Noordhout, CM, Majowicz, S, McDonald, SA, Pires, S, Scallan, E, Sripa, B, Thomas, MK, Verhoef, L, Wu, F & Zeilmaker, M 2015, 'World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010', PLoS Medicine, vol. 12, no. 12, e1001923. https://doi.org/10.1371/journal.pmed.1001923

TY - JOUR

T1 - World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010

AU - Havelaar, Arie H.

AU - Kirk, Martyn D.

AU - Torgerson, Paul R.

AU - Gibb, Herman J.

AU - Hald, Tine

AU - Lake, Robin J.

AU - Praet, Nicolas

AU - Bellinger, David C.

AU - de Silva, Nilanthi R.

AU - Gargouri, Neyla

AU - Speybroeck, Niko

AU - Cawthorne, Amy

AU - Mathers, Colin

AU - Stein, Claudia

AU - Angulo, Frederick J.

AU - Devleesschauwer, Brecht

AU - Adegoke, Gabriel O.

AU - Afshari, Reza

AU - Alasfoor, Deena

AU - Baines, Janis

AU - Balakrishnan, Kalpana

AU - Hamza, Wan Mansor Bin

AU - Black, Robert E.

AU - Bolger, P. Michael

AU - Chaicumpa, Wanpen

AU - Cravioto, Alejandro

AU - Döpfer, Dörte

AU - Ehiri, John E.

AU - Fazil, Aamir

AU - Ferreccio, Catterina

AU - Fèvre, Eric M.

AU - Hall, Gillian

AU - Kasuga, Fumiko

AU - Keddy, Karen H.

AU - Lanata, Claudio F.

AU - Lei, Haicho

AU - Liu, Xiumei

AU - Manyindo, Ben

AU - Nasinyama, George

AU - Ongolo-Zogo, Pierre

AU - Pitt, John I.

AU - Rokni, Mohammad B.

AU - Sripa, Banchob

AU - van Leeuwen, Rolaf

AU - Verger, Philippe

AU - Willingham, Arve Lee

AU - Zhou, Xiao Nong

AU - Aspinall, Willy

AU - Buchanan, Robert

AU - Budke, Christine

AU - Caipo, Marisa L.

AU - Carabin, Hélène

AU - Cole, Dana

AU - Cooke, Roger M.

AU - Crump, John A.

AU - El-Jardali, Fadi

AU - Fischer-Walker, Christa

AU - Fürst, Thomas

AU - Haagsma, Juanita A.

AU - Hall, Aron J.

AU - Henao, Olga

AU - Hoffmann, Sandra

AU - Jensen, Helen

AU - Jessani, Nasreen

AU - Koopmans, Marion P.G.

AU - Levine, Myron M.

AU - de Noordhout, Charline Maertens

AU - Majowicz, Shannon

AU - McDonald, Scott A.

AU - Pires, Sara

AU - Scallan, Elaine

AU - Sripa, Banchob

AU - Thomas, M. Kate

AU - Verhoef, Linda

AU - Wu, Felicia

AU - Zeilmaker, Marco

PY - 2015

Y1 - 2015

N2 - Illness and death from diseases caused by contaminated food are a constant threat to public health and a significant impediment to socio-economic development worldwide. To measure the global and regional burden of foodborne disease (FBD), the World Health Organization (WHO) established the Foodborne Disease Burden Epidemiology Reference Group (FERG), which here reports their first estimates of the incidence, mortality, and disease burden due to 31 foodborne hazards. We find that the global burden of FBD is comparable to those of the major infectious diseases, HIV/AIDS, malaria and tuberculosis. The most frequent causes of foodborne illness were diarrheal disease agents, particularly norovirus and Campylobacter spp. Diarrheal disease agents, especially non-typhoidal Salmonella enterica, were also responsible for the majority of deaths due to FBD. Other major causes of FBD deaths were Salmonella Typhi, Taenia solium and hepatitis A virus. The global burden of FBD caused by the 31 hazards in 2010 was 33 million Disability Adjusted Life Years (DALYs); children under five years old bore 40% of this burden. The 14 subregions, defined on the basis of child and adult mortality, had considerably different burdens of FBD, with the greatest falling on the subregions in Africa, followed by the subregions in South-East Asia and the Eastern Mediterranean D subregion. Some hazards, such as non-typhoidal S. enterica, were important causes of FBD in all regions of the world, whereas others, such as certain parasitic helminths, were highly localised. Thus, the burden of FBD is borne particularly by children under five years old–although they represent only 9% of the global population–and people living in low-income regions of the world. These estimates are conservative, i.e., underestimates rather than overestimates; further studies are needed to address the data gaps and limitations of the study. Nevertheless, all stakeholders can contribute to improvements in food safety throughout the food chain by incorporating these estimates into policy development at national and international levels.

AB - Illness and death from diseases caused by contaminated food are a constant threat to public health and a significant impediment to socio-economic development worldwide. To measure the global and regional burden of foodborne disease (FBD), the World Health Organization (WHO) established the Foodborne Disease Burden Epidemiology Reference Group (FERG), which here reports their first estimates of the incidence, mortality, and disease burden due to 31 foodborne hazards. We find that the global burden of FBD is comparable to those of the major infectious diseases, HIV/AIDS, malaria and tuberculosis. The most frequent causes of foodborne illness were diarrheal disease agents, particularly norovirus and Campylobacter spp. Diarrheal disease agents, especially non-typhoidal Salmonella enterica, were also responsible for the majority of deaths due to FBD. Other major causes of FBD deaths were Salmonella Typhi, Taenia solium and hepatitis A virus. The global burden of FBD caused by the 31 hazards in 2010 was 33 million Disability Adjusted Life Years (DALYs); children under five years old bore 40% of this burden. The 14 subregions, defined on the basis of child and adult mortality, had considerably different burdens of FBD, with the greatest falling on the subregions in Africa, followed by the subregions in South-East Asia and the Eastern Mediterranean D subregion. Some hazards, such as non-typhoidal S. enterica, were important causes of FBD in all regions of the world, whereas others, such as certain parasitic helminths, were highly localised. Thus, the burden of FBD is borne particularly by children under five years old–although they represent only 9% of the global population–and people living in low-income regions of the world. These estimates are conservative, i.e., underestimates rather than overestimates; further studies are needed to address the data gaps and limitations of the study. Nevertheless, all stakeholders can contribute to improvements in food safety throughout the food chain by incorporating these estimates into policy development at national and international levels.

UR - http://www.scopus.com/inward/record.url?scp=84953218815&partnerID=8YFLogxK

U2 - 10.1371/journal.pmed.1001923

DO - 10.1371/journal.pmed.1001923

M3 - Review article

SN - 1549-1277

VL - 12

JO - PLoS Medicine

JF - PLoS Medicine

IS - 12

M1 - e1001923

ER -

World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010

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