World Health Organization Ranking of Antimicrobials According to Their Importance in Human Medicine: A Critical Step for Developing Risk Management Strategies to Control Antimicrobial Resistance from Food Animal Production

Peter C. Collignon*, John M. Conly, Antoine Andremont, Scott A. McEwen, Awa Aidara-Kane, Patricia M. Griffin, Yvonne Agerso, Tran Dang Ninh, Pilar Donado-Godoy, Paula Fedorka-Cray, Heriberto Fernandez, Marcelo Galas, Rebecca Irwin, Beth Karp, Gassan Matar, Patrick McDermott, Eric Mitema, Richard Reid-Smith, H. Morgan Scott, Ruby SinghCaroline Smith Dewaal, John Stelling, Mark Toleman, Haruo Watanabe, Gun Jo Woo

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    210 Citations (Scopus)

    Abstract

    Antimicrobial use in food animals selects for antimicrobial resistance in bacteria, which can spread to people. Reducing use of antimicrobials - particularly those deemed to be critically important for human medicine - in food production animals continues to be an important step for preserving the benefits of these antimicrobials for people. The World Health Organization ranking of antimicrobials according to their relative importance in human medicine was recently updated. Antimicrobials considered the highest priority among the critically important antimicrobials were quinolones, third- and fourth-generation cephalosporins, macrolides and ketolides, and glycopeptides. The updated ranking allows stakeholders in the agriculture sector and regulatory agencies to focus risk management efforts on drugs used in food animals that are the most important to human medicine. In particular, the current large-scale use of fluoroquinolones, macrolides, and third-generation cephalosporins and any potential use of glycopeptides and carbapenems need to be addressed urgently.

    Original languageEnglish
    Pages (from-to)1087-1093
    Number of pages7
    JournalClinical Infectious Diseases
    Volume63
    Issue number8
    DOIs
    Publication statusPublished - 15 Oct 2016

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