Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in french polynesia and fiji

Alasdair D. Henderson, Maite Aubry, Mike Kama, Jessica Vanhomwegen, Anita Teissier, Teheipuaura Mariteragi-Helle, Tuterarii Paoaafaite, Yoann Teissier, Jean Claude Manuguerra, John Edmunds, Jimmy Whitworth, Conall H. Watson, Colleen L. Lau, Van Mai Cao-Lormeau*, Adam J. Kucharski

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period.

    Original languageEnglish
    Article numbere48460
    JournaleLife
    Volume9
    DOIs
    Publication statusPublished - Jan 2020

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