TY - JOUR
T1 - Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in french polynesia and fiji
AU - Henderson, Alasdair D.
AU - Aubry, Maite
AU - Kama, Mike
AU - Vanhomwegen, Jessica
AU - Teissier, Anita
AU - Mariteragi-Helle, Teheipuaura
AU - Paoaafaite, Tuterarii
AU - Teissier, Yoann
AU - Manuguerra, Jean Claude
AU - Edmunds, John
AU - Whitworth, Jimmy
AU - Watson, Conall H.
AU - Lau, Colleen L.
AU - Cao-Lormeau, Van Mai
AU - Kucharski, Adam J.
N1 - Publisher Copyright:
© Henderson et al.
PY - 2020/1
Y1 - 2020/1
N2 - It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period.
AB - It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period.
UR - http://www.scopus.com/inward/record.url?scp=85078481799&partnerID=8YFLogxK
U2 - 10.7554/eLife.48460
DO - 10.7554/eLife.48460
M3 - Article
SN - 2050-084X
VL - 9
JO - eLife
JF - eLife
M1 - e48460
ER -